Polygot
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How to take Polygot

Polygot is taken to treat migraine, headache against a background of arterial hypotension. It is taken orally, 1-2 tablets during a headache attack and then 1 tablet 2-3 times a day for several days. The maximum single dose is 2 tablets, the daily dose is 4 tablets. It is not recommended to use for a long time (to avoid ergotism): after 7 days of use in cases requiring longer treatment, take a break (for 3-4 days). The composition of the drug Polygot: Active ingredients: caffeine – 100 mg and ergotamine tartrate – 1 mg; Excipients: excipients: potato starch, talc, stearic acid, sucrose, dextrose.

How to take Polygot

Polygot is a combination drug. Caffeine causes stimulation of the central nervous system, mainly in the cerebral cortex, respiratory and vasomotor centers. It increases mental and physical performance, reduces sleepiness and fatigue. It has a pronounced cardiotonic effect: it increases strength and heart rate, increases blood pressure in hypotension. Ergotamine has a vasoconstrictor effect. Caffeine accelerates absorption of ergotamine. Pharmacokinetics. After oral administration, about 62% of ergotamine is absorbed in the gastrointestinal tract. Maximum plasma concentrations are achieved 2 hours after oral administration. Binding to plasma proteins is 98%. Ergotamine is metabolized in the liver to form pharmacologically active metabolites. Ergotamine is eliminated mainly with bile both unchanged and as metabolites. Excretion is biphasic, with half-lives of 2.7 hours and 21 hours for I and II phases, respectively. After oral administration, caffeine is absorbed quickly and almost completely. Binding with plasma proteins is 35%. Caffeine is almost completely metabolized in the body. Metabolites are excreted mainly with urine. The elimination half-life is about 3.5 hours.

How to take Polygot

Despite the fact that migraine has been known since ancient times, the principle of pain formation has not yet been fully studied. It is very likely that migraine is not associated with intracranial and arterial pressure, and is not caused by tumors and trauma, and is not a consequence of mental tension. A correlation between migraine and stroke has been observed, but whether migraine is a consequence of stroke or its cause is not definitively known.

Currently, there are several hypotheses explaining the mechanics of the pain, and all of them, in one way or another, concern the cerebral vessels. This seems to be the reason for the pulsating character of the pain. Among the most possible causes of the pain syndrome is the narrowing of the vascular lumen, which causes insufficient blood supply to certain parts of the brain, which is why migraine pain is clearly localized. According to another version, for various reasons, the vessels expand unevenly, provoking a reaction in the form of pain. If the internal mechanics of a migraine is of more interest to specialists, the factors directly provoking the attack are a pressing issue for ordinary patients.